Publications


  1. Jiajiu Shaw, Ben Chen, Paul Wooley, Wen-Hsin Huang, An-Rong Lee and Dustin Zeng. Anti-inflammatory and Anti-arthritic Effects of a Novel Leflunomide Analogue, UTL-5b (GBL-5b). Am J Biomed Sci, 2011, 3(1), 31-39. PMID 21253441 http://www.nwpii.com/ajbms/papers/2011_1_04_Abs.htm


  2. Jiajiu Shaw, Ben Chen, Wen-Hsin Huang, An-Rong Lee, Joseph Media, and Frederick A. Valeriote. The small-molecule TNF-α modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo. J Exp Therapeutics and Oncology, 2011, 9 (2), 129-137. PMID: 21699020 http://www.oldcitypublishing.com/JETO/JETOabstracts/JETO9.2abstracts/JETOv9n2p129-137Shaw.html


  3. Jiajiu Shaw, Ben Chen, Paul Wooley, Bruce Palfey, An-Rong Lee, Wen-Hsin Huang, and Dustin Zeng. A Novel Leflunomide Analog, UTL-5b (GBL-5b), Suppresses JAK3, MAP3K2, and LITAF Genes. Am J Biomed Sci, 2011, 3(3), 218-227; doi: 10.5099/aj110300219 http://www.nwpii.com/ajbms/papers/2011_3_07_Abs.htm


  4. Jiajiu Shaw, Ben Chen, Jean P. Bourgault, Hao Jiang, Narendra Kumar , Jayshree Mishra, Frederick A. Valeriote, Joe Media, Kevin Bobbitt, Halina Pietraszkiewicz, Matthew Edelstein, Peter R. Andreana. Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer. Am J Biomed Sci, 2011, 4(1), 14-25; doi: 10.5099/aj120100014 http://www.nwpii.com/ajbms/papers/2012_1_02_Abs.htm


  5. Jiajiu Shaw, Brian Shay, Jack Jiang, Frederick Valeriote and Ben Chen. Metabolism studies of a small-molecule tumor necrosis factor-alpha (TNF-α) inhibitor, UTL-5b (GBL-5b). European Journal of Drug Metabolism and Pharmacokinetics, 2012, 37(2), 83-89; doi: 10.1007/s13318-011-0072-7 http://www.springerlink.com/content/45200442k368251q/


  6. Jiajiu Shaw, Jie Zhang, Ming Zhang, Frederick Valeriote, Ben Chen. Pretreatment with a Small-Molecule Tumor Necrosis Factor-Alpha (TNF-α) Inhibitor, UTL-5g, Reduced Radiation-Induced Acute Liver Toxicity in Mice. Am J Biomed Sci, 2012, 4(2), 123-131; doi: 10.5099/aj120200123 http://www.nwpii.com/ajbms/papers/2012_1_12_Abs.htm


  7. Ravindra A. De Silva, Dananjaya K. Appulage, Halina Pietraszkiewicz, Kevin R. Bobbitt, Joe Media, JiaJiu Shaw, Fred A. Valeriote, Peter R. Andreana. The entirely carbohydrate immunogen Tn-PS A1 induces a cancer cell selective immune response and cytokine IL-17. Cancer Immunol Immunother, 2012, 61(4), 581-585; doi: 10.1007/s00262-012-1205-9 http://link.springer.com/article/10.1007%2Fs00262-012-1205-9


  8. J Mishra, J Dromund, SH Quazi, SS Karanki, JJ Shaw, B Chen, N Kumar. Prospective of Colon Cancer Treatments and Scope for Combinatorial Approach to Enhanced Cancer Cell Apoptosis. Critical Reviews in Oncology/Hematology, Published online, Oct 2012; doi:10.1016/j.critrevonc.2012.09.014 http://www.croh-online.com/article/S1040-8428(12)00197-7/abstract


  9. Kenneth H Swartz, Frederick A Valeriote, Joseph Media, Tyler A Johnson, Karen Tenney, Phillip Crews and Jiajiu Shaw. Development and Validation of a Simple Method for the Detection of Fascaplysin in Plasma. Journal of Analytical & Bioanalytical Techniques, 2012, 3(6); doi:10.4172/2155-9872.1000150 http://www.omicsonline.org/2155-9872/2155-9872-abstract.php?abstract_id=9343


  10. Jiajiu Shaw, Joseph Media, Ben Chen, Fredrick Valeriote. The small-molecule TNF-α inhibitor, UTL-5g, delays deaths and increases survival rates for mice treated with high doses of cisplatin. Cancer Chemotherapy and Pharmacology, 2013, 72(3), 703-707; doi:10.1007/s00280-013-2236-4 http://link.springer.com/content/pdf/10.1007/s00280-013-2236-4.pdf


  11. Kenneth Swartz, Yiguan Zhang, Frederick Valeriote, Ben Chen, Jiajiu Shaw. Using a simple HPLC approach to identify the enzymatic products of UTL-5g, a small molecule TNF-α inhibitor, from porcine esterase and from rabbit esterase. Journal of Chromatography B, 2013, 940, 1-6; doi: 10.1016/j.jchromb.2013.09.021. http://www.sciencedirect.com/science/article/pii/S1570023213005035


  12. Song Y, Zhang Y, Lee AR, Huang WH, Chen B, Palfey B, Shaw J. Comparison of two molecular scaffolds, 5-methylisoxazole-3-carboxamide and 5-methylisoxazole-4-carboxamide. Europe PubMed Central, 2014, 20(1), 146-152; doi: 10.2174/13816128113199990584. http://europepmc.org/abstract/med/23944378/2


  13. Yiguan Zhang, Yongxin Tang, Ben Chen, Frederick Valeriote, Xiaohui Li, and Jiajiu Shaw. UTL-5g lowers elevated blood levels of TNF-a and TGF-β and increases survival rates in animals treated with LPS/D-(+)-galactosamine. Am J Biomed Sci, 2014, 6(2), 128-138; doi:10.5099/aj140200128. http://www.nwpii.com/ajbms/papers/2014_2_06_Abs.shtml


  14. YongBo Liu, Xiaohua Gao, Dorrah Deeb, Chris Brigolin, Yiguan Zhang, JiaJiu Shaw, Kirit Pindolia and Subhash C. Gautam. Ubiquitin-proteasomal degradation of antiapoptotic facilitates induction of apoptosis in prostate cancer cells by pristimerin. Int J Oncology, 2014, 45: 1735-1741; doi: 10.3892/ijo.2014.25618. http://www.spandidos-publications.com/10.3892/ijo.2014.2561


  15. Stephen Brown, Frederick Valeriote, Ben Chen, Kevin Bobbitt, Joseph Media, Halina Pietraszkiewicz, Jiajiu Shaw. UTL-5g lowers levels of TGF-β and TNF-α elevated by lung irradiation and does not affect tumor-response to irradiation. Am J Biomed Sci, 2014, 6(3), 157-165; doi: 10.5099/aj140300157. http://www.nwpii.com/ajbms/papers/AJBMS_2014_3_02.pdf


  16. Jianmei Wu, Jiajiu Shaw, Sarah Dubaisi, Frederick Valeriote, Jing Li. In vitro metabolism and drug-drug interaction potential of UTL-5g, a novel chemo- and radio-protective agent. Drug Metab Disposi, 2014, 42:2058–2067; doi: 10.1124/dmd.114.060095. http://dmd.aspetjournals.org/content/early/2014/09/23/dmd.114.060095.abstract


  17. Frederick Valeriote, Ben Chen, Joseph Media, Kevin R. Bobbitt, Jiajiu Shaw. Enhancement of Bone Marrow CD41+ Megakaryocytes as well as Modulation of TNF-α, IL-12, and IL-5 by a Novel Small Molecule, UTL-5g, in Mice Treated with Cisplatin. Am J Biomed Sci, 2015, 7(1), 1-8. doi: 10.5099/aj150100001


  18. Jiajiu Shaw, Richard Wiegand, Jianmei Wu, Xun Bao, Frederick Valeriote, Jing Li. A Liquid Chromatography with Tandem Mass Spectrometry Method for Simultaneous Determination of UTL-5g and Its Metabolites in Human Plasma. Chromatography B, 2015, 991, 92-98. doi:10.1016/j.jchromb.2015.04.015


  19. Yiguan Zhang, Frederick Valeriote, Kenneth Swartz, Ben Chen, Mark T. Hamann, Douglas L. Rodenburg, James D. McChesney, and Jiajiu Shaw. HPLC Plasma Assay of a Novel Anti-MRSA Compound, Kaempferol-3-O-Alpha-L-(2",3"-di-p-coumaroyl)rhamnoside, from Sycamore Leaves. Natural Product Communications, 2015, Vol. 10 (8), 1383-1386.


  20. B. Chen, W-H. Huang, A-R. Lee, J. Media, F. Valeriote, J. Shaw. Chemosenstizing Effects of a Novel Anti-inflammatory Small Molecule, UTL-5g, and Its Analogs. Am J Biomed Sci, 2015, 7(3), 190-197. doi: 10.5099/aj150300190